Guanabenz Treatment Accelerates Disease in a Mutant SOD1 Mouse Model of ALS

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by loss of motor neurons. The mechanisms leading to motor neuron degeneration in ALS are unclear. However, there is evidence for involvement of endoplasmic reticulum (ER) stress and the unfolded protein resp...

Descripción completa

Detalles Bibliográficos
Autores principales: Vieira, Fernando G., Ping, Qinggong, Moreno, Andy J., Kidd, Joshua D., Thompson, Kenneth, Jiang, Bingbing, Lincecum, John M., Wang, Monica Z., De Zutter, Gerard S., Tassinari, Valerie R., Levine, Beth, Hatzipetros, Theo, Gill, Alan, Perrin, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545826/
https://www.ncbi.nlm.nih.gov/pubmed/26288094
http://dx.doi.org/10.1371/journal.pone.0135570

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545826/
https://www.ncbi.nlm.nih.gov/pubmed/26288094
http://dx.doi.org/10.1371/journal.pone.0135570

Ejemplares similares