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Foxp3-modified bone marrow mesenchymal stem cells promotes liver allograft tolerance through the generation of regulatory T cells in rats
BACKGROUND: The transcription factor forkhead box P3 (Foxp3) is a master regulatory gene necessary for the development and function of CD4(+)CD25(+) regulatory T cells (Tregs). Mesenchymal stem cells (MSC) have recently emerged as promising candidates for cell-based immunosuppression/tolerance induc...
Autores principales: | Qi, Haizhi, Chen, Guangshun, Huang, Yaxun, Si, Zhongzhou, Li, Jiequn |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545923/ https://www.ncbi.nlm.nih.gov/pubmed/26293578 http://dx.doi.org/10.1186/s12967-015-0638-2 |
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