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Intracellular amyloid β oligomers impair organelle transport and induce dendritic spine loss in primary neurons
INTRODUCTION: Synaptic dysfunction and intracellular transport defects are early events in Alzheimer’s disease (AD). Extracellular amyloid β (Aβ) oligomers cause spine alterations and impede the transport of proteins and organelles such as brain-derived neurotrophic factor (BDNF) and mitochondria th...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546183/ https://www.ncbi.nlm.nih.gov/pubmed/26293809 http://dx.doi.org/10.1186/s40478-015-0230-2 |