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Intracellular amyloid β oligomers impair organelle transport and induce dendritic spine loss in primary neurons

INTRODUCTION: Synaptic dysfunction and intracellular transport defects are early events in Alzheimer’s disease (AD). Extracellular amyloid β (Aβ) oligomers cause spine alterations and impede the transport of proteins and organelles such as brain-derived neurotrophic factor (BDNF) and mitochondria th...

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Detalles Bibliográficos
Autores principales:	Umeda, Tomohiro, Ramser, Elisa M., Yamashita, Minato, Nakajima, Koichi, Mori, Hiroshi, Silverman, Michael A., Tomiyama, Takami
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546183/ https://www.ncbi.nlm.nih.gov/pubmed/26293809 http://dx.doi.org/10.1186/s40478-015-0230-2

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