Filling the gap: Micro-C accesses the nucleosomal fiber at 100–1000 bp resolution

The fine three-dimensional structure of the nucleosomal fiber has remained elusive to genome-wide chromosome conformation capture (3C) approaches. A new study mapping contacts at the single nucleosome level (Micro-C) reveals topological interacting domains along budding yeast chromosomes. These doma...

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Detalles Bibliográficos
Autores principales: Mozziconacci, Julien, Koszul, Romain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546249/
https://www.ncbi.nlm.nih.gov/pubmed/26294274
http://dx.doi.org/10.1186/s13059-015-0744-8
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author Mozziconacci, Julien
Koszul, Romain
author_facet Mozziconacci, Julien
Koszul, Romain
author_sort Mozziconacci, Julien
collection PubMed
description The fine three-dimensional structure of the nucleosomal fiber has remained elusive to genome-wide chromosome conformation capture (3C) approaches. A new study mapping contacts at the single nucleosome level (Micro-C) reveals topological interacting domains along budding yeast chromosomes. These domains encompass one to five consecutive genes and are delimited by highly active promoters.
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spelling pubmed-45462492015-08-23 Filling the gap: Micro-C accesses the nucleosomal fiber at 100–1000 bp resolution Mozziconacci, Julien Koszul, Romain Genome Biol Research Highlight The fine three-dimensional structure of the nucleosomal fiber has remained elusive to genome-wide chromosome conformation capture (3C) approaches. A new study mapping contacts at the single nucleosome level (Micro-C) reveals topological interacting domains along budding yeast chromosomes. These domains encompass one to five consecutive genes and are delimited by highly active promoters. BioMed Central 2015-08-21 2015 /pmc/articles/PMC4546249/ /pubmed/26294274 http://dx.doi.org/10.1186/s13059-015-0744-8 Text en © Mozziconacci and Koszul. 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Highlight
Mozziconacci, Julien
Koszul, Romain
Filling the gap: Micro-C accesses the nucleosomal fiber at 100–1000 bp resolution
title Filling the gap: Micro-C accesses the nucleosomal fiber at 100–1000 bp resolution
title_full Filling the gap: Micro-C accesses the nucleosomal fiber at 100–1000 bp resolution
title_fullStr Filling the gap: Micro-C accesses the nucleosomal fiber at 100–1000 bp resolution
title_full_unstemmed Filling the gap: Micro-C accesses the nucleosomal fiber at 100–1000 bp resolution
title_short Filling the gap: Micro-C accesses the nucleosomal fiber at 100–1000 bp resolution
title_sort filling the gap: micro-c accesses the nucleosomal fiber at 100–1000 bp resolution
topic Research Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546249/
https://www.ncbi.nlm.nih.gov/pubmed/26294274
http://dx.doi.org/10.1186/s13059-015-0744-8
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