The beneficial effect of Zinc(II) on low-dose chemotherapeutic sensitivity involves p53 activation in wild-type p53-carrying colorectal cancer cells

BACKGROUND: Activation of wild-type p53 in response to genotoxic stress occurs through different mechanisms including protein conformation, posttranslational modifications, and nuclear localization, leading to DNA binding to sequence-specific promoters. Zinc ion plays a crucial role in stabilizing p...

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Detalles Bibliográficos
Autores principales: Garufi, Alessia, Ubertini, Valentina, Mancini, Francesca, D’Orazi, Valerio, Baldari, Silvia, Moretti, Fabiola, Bossi, Gianluca, D’Orazi, Gabriella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546314/
https://www.ncbi.nlm.nih.gov/pubmed/26297485
http://dx.doi.org/10.1186/s13046-015-0206-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546314/
https://www.ncbi.nlm.nih.gov/pubmed/26297485
http://dx.doi.org/10.1186/s13046-015-0206-x

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