Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened

An essential role for Hedgehog (Hh) signaling in human cancer has been established beyond doubt. At present, targeting Hh signaling has mainly been investigated with SMO inhibitors. Unfortunately, resistance against currently used SMO inhibitors has already been observed in basal cell carcinoma (BCC...

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Detalles Bibliográficos
Autores principales: Gonnissen, Annelies, Isebaert, Sofie, Haustermans, Karin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546439/
https://www.ncbi.nlm.nih.gov/pubmed/26053182

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546439/
https://www.ncbi.nlm.nih.gov/pubmed/26053182

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