AKT inhibition overcomes rapamycin resistance by enhancing the repressive function of PRAS40 on mTORC1/4E-BP1 axis

The mTORC1 inhibitors, rapamycin and its analogs, are known to show only modest antitumor activity in clinic, but the underlying mechanisms remain largely elusive. Here, we found that activated AKT signaling is associated with rapamycin resistance in breast and colon cancers by sustained phosphoryla...

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Detalles Bibliográficos
Autores principales: Mi, Wenting, Ye, Qing, Liu, Side, She, Qing-Bai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546444/
https://www.ncbi.nlm.nih.gov/pubmed/25961827

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546444/
https://www.ncbi.nlm.nih.gov/pubmed/25961827

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