The indirect NMDAR inhibitor flupirtine induces sustained post-ischemic recovery, neuroprotection and angioneurogenesis

N-methyl-D-aspartate receptor (NMDAR) activation induces excitotoxicity, contributing to post-stroke brain injury. Hitherto, NMDAR deactivation failed in clinical trials due to insufficient pre-clinical study designs and drug toxicity. Flupirtine is an indirect NMDAR antagonist being used as analges...

Descripción completa

Detalles Bibliográficos
Autores principales: Jaeger, Hanna M., Pehlke, Jens R., Kaltwasser, Britta, Kilic, Ertugrul, Bähr, Mathias, Hermann, Dirk M., Doeppner, Thorsten R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper: Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546449/
https://www.ncbi.nlm.nih.gov/pubmed/26050199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546449/
https://www.ncbi.nlm.nih.gov/pubmed/26050199

Ejemplares similares