NKX2-1-mediated p53 expression modulates lung adenocarcinoma progression via modulating IKKβ/NF-κB activation

NKX2-1 plays a dual role in lung adenocarcinoma progression, but the underling mechanism is not fully understood. In the present study, we provide evidence that NKX2-1 directly regulates p53 transcription, and in turn, NKX2-1 elevates the mutant p53/NF-Y complex to up-regulate IKKβ transcription in...

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Detalles Bibliográficos
Autores principales: Chen, Po-Ming, Wu, Tzu-Chin, Cheng, Ya-Wen, Chen, Chih-Yi, Lee, Huei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546466/
https://www.ncbi.nlm.nih.gov/pubmed/25881545

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546466/
https://www.ncbi.nlm.nih.gov/pubmed/25881545

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