Wnt-C59 arrests stemness and suppresses growth of nasopharyngeal carcinoma in mice by inhibiting the Wnt pathway in the tumor microenvironment

Wnt/β-catenin signaling is responsible for the generation of cancer stem cells (CSCs) in many human tumors, including nasopharyngeal carcinoma (NPC). Recent studies demonstrate that Wnt or PORCN inhibitor, Wnt-C59, inhibits tumor growth in MMTV-WNT1 transgenic mice. The effect of Wnt-C59 in human tu...

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Detalles Bibliográficos
Autores principales: Cheng, Yue, Phoon, Yee Peng, Jin, Xiwan, Chong, Shing Yee Steffi, Ip, Joseph Chok Yan, Wong, Bonnie Wing Yan, Lung, Maria Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546477/
https://www.ncbi.nlm.nih.gov/pubmed/25980501

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546477/
https://www.ncbi.nlm.nih.gov/pubmed/25980501

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