Lysine-specific demethylase (LSD1/KDM1A) and MYCN cooperatively repress tumor suppressor genes in neuroblastoma

The chromatin-modifying enzyme lysine-specific demethylase 1, KDM1A/LSD1 is involved in maintaining the undifferentiated, malignant phenotype of neuroblastoma cells and its overexpression correlated with aggressive disease, poor differentiation and infaust outcome. Here, we show that LSD1 physically...

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Detalles Bibliográficos
Autores principales: Amente, Stefano, Milazzo, Giorgio, Sorrentino, Maria Cristina, Ambrosio, Susanna, Di Palo, Giacomo, Lania, Luigi, Perini, Giovanni, Majello, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546488/
https://www.ncbi.nlm.nih.gov/pubmed/26062444

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546488/
https://www.ncbi.nlm.nih.gov/pubmed/26062444

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