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Increased Stiffness in Aged Skeletal Muscle Impairs Muscle Progenitor Cell Proliferative Activity

BACKGROUND: Skeletal muscle aging is associated with a decreased regenerative potential due to the loss of function of endogenous stem cells or myogenic progenitor cells (MPCs). Aged skeletal muscle is characterized by the deposition of extracellular matrix (ECM), which in turn influences the biomec...

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Detalles Bibliográficos
Autores principales: Lacraz, Grégory, Rouleau, André-Jean, Couture, Vanessa, Söllrald, Thomas, Drouin, Geneviève, Veillette, Noémie, Grandbois, Michel, Grenier, Guillaume
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546553/
https://www.ncbi.nlm.nih.gov/pubmed/26295702
http://dx.doi.org/10.1371/journal.pone.0136217