Biophysical Characterization of Essential Phosphorylation at the Flexible C-Terminal Region of C-Raf with 14-3-3ζ Protein

Phosphorylation at the C-terminal flexible region of the C-Raf protein plays an important role in regulating its biological activity. Auto-phosphorylation at serine 621 (S621) in this region maintains C-Raf stability and activity. This phosphorylation mediates the interaction between C-Raf and scaff...

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Detalles Bibliográficos
Autores principales: Ghosh, Anirban, Ratha, Bhisma Narayan, Gayen, Nilanjan, Mroue, Kamal H., Kar, Rajiv K., Mandal, Atin K., Bhunia, Anirban
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546627/
https://www.ncbi.nlm.nih.gov/pubmed/26295714
http://dx.doi.org/10.1371/journal.pone.0135976

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546627/
https://www.ncbi.nlm.nih.gov/pubmed/26295714
http://dx.doi.org/10.1371/journal.pone.0135976

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