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Over-Expression of Cysteine Leucine Rich Protein Is Related to SAG Resistance in Clinical Isolates of Leishmania donovani

BACKGROUND: Resistance emergence against antileishmanial drugs, particularly Sodium Antimony Gluconate (SAG) has severely hampered the therapeutic strategy against visceral leishmaniasis, the mechanism of resistance being indistinguishable. Cysteine leucine rich protein (CLrP), was recognized as one...

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Detalles Bibliográficos
Autores principales: Das, Sanchita, Shah, Priyanka, Tandon, Rati, Yadav, Narendra Kumar, Sahasrabuddhe, Amogh A., Sundar, Shyam, Siddiqi, Mohammad Imran, Dube, Anuradha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546639/
https://www.ncbi.nlm.nih.gov/pubmed/26295340
http://dx.doi.org/10.1371/journal.pntd.0003992