Cargando…

Over-Expression of Cysteine Leucine Rich Protein Is Related to SAG Resistance in Clinical Isolates of Leishmania donovani

BACKGROUND: Resistance emergence against antileishmanial drugs, particularly Sodium Antimony Gluconate (SAG) has severely hampered the therapeutic strategy against visceral leishmaniasis, the mechanism of resistance being indistinguishable. Cysteine leucine rich protein (CLrP), was recognized as one...

Descripción completa

Detalles Bibliográficos
Autores principales:	Das, Sanchita, Shah, Priyanka, Tandon, Rati, Yadav, Narendra Kumar, Sahasrabuddhe, Amogh A., Sundar, Shyam, Siddiqi, Mohammad Imran, Dube, Anuradha
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546639/ https://www.ncbi.nlm.nih.gov/pubmed/26295340 http://dx.doi.org/10.1371/journal.pntd.0003992

Ejemplares similares

Over-Expression of 60s Ribosomal L23a Is Associated with Cellular Proliferation in SAG Resistant Clinical Isolates of Leishmania donovani
por: Das, Sanchita, et al.
Publicado: (2013)

Immunogenicity and Protective Efficacy of T-Cell Epitopes Derived From Potential Th1 Stimulatory Proteins of Leishmania (Leishmania) donovani
por: Joshi, Sumit, et al.
Publicado: (2019)

Nucleosomal Histone Proteins of L. donovani: A Combination of Recombinant H2A, H2B, H3 and H4 Proteins Were Highly Immunogenic and Offered Optimum Prophylactic Efficacy against Leishmania Challenge in Hamsters
por: Baharia, Rajendra K., et al.
Publicado: (2014)

Correction: Nucleosomal Histone Proteins of L. donovani: A Combination of Recombinant H2A, H2B, H3 and H4 Proteins Were Highly Immunogenic and Offered Optimum Prophylactic Efficacy against Leishmania Challenge in Hamsters
por: Baharia, Rajendra K., et al.
Publicado: (2021)

Comparative Analysis of Cellular Immune Responses in Treated Leishmania Patients and Hamsters against Recombinant Th1 Stimulatory Proteins of Leishmania donovani
por: Joshi, Sumit, et al.
Publicado: (2016)

Correction: Recombinant NAD-dependent SIR-2 Protein of Leishmania donovani: Immunobiochemical Characterization as a Potential Vaccine against Visceral Leishmaniasis
por: Baharia, Rajendra K, et al.
Publicado: (2015)

Recombinant NAD-dependent SIR-2 Protein of Leishmania donovani: Immunobiochemical Characterization as a Potential Vaccine against Visceral Leishmaniasis
por: Baharia, Rajendra K, et al.
Publicado: (2015)

A Chimera of Th1 Stimulatory Proteins of Leishmania donovani Offers Moderate Immunotherapeutic Efficacy with a Th1-Inclined Immune Response against Visceral Leishmaniasis
por: Ratnapriya, Sneha, et al.
Publicado: (2021)

Leishmania donovani: Immunostimulatory Cellular Responses of Membrane and Soluble Protein Fractions of Splenic Amastigotes in Cured Patient and Hamsters
por: Kumari, Shraddha, et al.
Publicado: (2012)

Characterization of Glycolytic Enzymes - rAldolase and rEnolase of Leishmania donovani, Identified as Th1 Stimulatory Proteins, for Their Immunogenicity and Immunoprophylactic Efficacies against Experimental Visceral Leishmaniasis
por: Gupta, Reema, et al.
Publicado: (2014)

Evaluation of Leishmania donovani Protein Disulfide Isomerase as a Potential Immunogenic Protein/Vaccine Candidate against Visceral Leishmaniasis
por: Kushawaha, Pramod Kumar, et al.
Publicado: (2012)

Leishmania donovani Triose Phosphate Isomerase: A Potential Vaccine Target against Visceral Leishmaniasis
por: Kushawaha, Pramod K., et al.
Publicado: (2012)

Seasonal Variation in the Prevalence of Sand Flies Infected with Leishmania donovani
por: Tiwary, Puja, et al.
Publicado: (2013)

Mapping the Antigenicity of the Parasites in Leishmania donovani Infection by Proteome Serology
por: Forgber, Michael, et al.
Publicado: (2006)

Cloning, Expression and Purification of L. Donovani Specific Antigen for Serodiagnosis of Visceral Leishmaniasis
por: Kumar, Dinesh, et al.
Publicado: (2013)

Leishmania donovani-Induced Increase in Macrophage Bcl-2 Favors Parasite Survival
por: Pandey, Rajeev Kumar, et al.
Publicado: (2016)

Role of Efflux Pumps and Intracellular Thiols in Natural Antimony Resistant Isolates of Leishmania donovani
por: Rai, Smita, et al.
Publicado: (2013)

Th1 Stimulatory Proteins of Leishmania donovani: Comparative Cellular and Protective Responses of rTriose Phosphate Isomerase, rProtein Disulfide Isomerase and rElongation Factor-2 in Combination with rHSP70 against Visceral Leishmaniasis
por: Jaiswal, Anil Kumar, et al.
Publicado: (2014)

An orally effective dihydropyrimidone (DHPM) analogue induces apoptosis-like cell death in clinical isolates of Leishmania donovani overexpressing pteridine reductase 1
por: Singh, Neeloo, et al.
Publicado: (2009)

Risk Factors for Visceral Leishmaniasis and Asymptomatic Leishmania donovani Infection in India and Nepal
por: Picado, Albert, et al.
Publicado: (2014)

Transcriptome profiling identifies genes/pathways associated with experimental resistance to paromomycin in Leishmania donovani
por: Verma, Aditya, et al.
Publicado: (2017)

Latent Infection with Leishmania donovani in Highly Endemic Villages in Bihar, India
por: Hasker, Epco, et al.
Publicado: (2013)

Prophylactic interferon-γ and interleukin-17 facilitate parasite clearance in experimental visceral leishmaniasis
por: Kumar, Prabin, et al.
Publicado: (2019)

LEISHMANIA DONOVANI IN THE PERIPHERAL BLOOD
por: Young, Charles W., et al.
Publicado: (1923)

An Insight Into Systemic Immune Response in Leishmania donovani Mediated Atypical Cutaneous Leishmaniasis in the New Endemic State of Himachal Pradesh, India
por: Thakur, Lovlesh, et al.
Publicado: (2022)

Correction: Latent Infection with Leishmania donovani in Highly Endemic Villages in Bihar, India
por: Hasker, Epco, et al.
Publicado: (2013)

Leishmania actin binds and nicks kDNA as well as inhibits decatenation activity of type II topoisomerase
por: Kapoor, Prabodh, et al.
Publicado: (2010)

SOLiD™ Sequencing of Genomes of Clinical Isolates of Leishmania donovani from India Confirm Leptomonas Co-Infection and Raise Some Key Questions
por: Singh, Neeloo, et al.
Publicado: (2013)

Tissue/Biofluid Specific Molecular Cartography of Leishmania donovani Infected BALB/c Mice: Deciphering Systemic Reprogramming
por: Das, Sanchita, et al.
Publicado: (2021)

Proteomic analysis of the secretome of Leishmania donovani
por: Silverman, J Maxwell, et al.
Publicado: (2008)

Surface antigens of Leishmania donovani promastigotes
Publicado: (1983)

Vaccine Development Against Leishmania donovani
por: Das, Amrita, et al.
Publicado: (2012)

Leishmania donovani bodies in bone marrow
por: Ali, Natasha, et al.
Publicado: (2014)

Isolation and characterisation of Leishmania donovani protein antigens from urine of visceral leishmaniasis patients
por: Marlais, Tegwen, et al.
Publicado: (2020)

Interferon-Gamma Release Assay (Modified QuantiFERON) as a Potential Marker of Infection for Leishmania donovani, a Proof of Concept Study
por: Gidwani, Kamlesh, et al.
Publicado: (2011)

L-Asparaginase of Leishmania donovani: Metabolic target and its role in Amphotericin B resistance
por: Singh, Jasdeep, et al.
Publicado: (2017)

Incidence of Symptomatic and Asymptomatic Leishmania donovani Infections in High-Endemic Foci in India and Nepal: A Prospective Study
por: Ostyn, Bart, et al.
Publicado: (2011)

Imipramine Is an Orally Active Drug against Both Antimony Sensitive and Resistant Leishmania donovani Clinical Isolates in Experimental Infection
por: Mukherjee, Sandip, et al.
Publicado: (2012)

Genome-wide SNP and microsatellite variation illuminate population-level epidemiology in the Leishmania donovani species complex
por: Downing, Tim, et al.
Publicado: (2012)

The identification of kala-azar and the discovery of Leishmania donovani.
por: Gibson, M E
Publicado: (1983)

Cannot write session to /tmp/vufind_sessions/sess_tj5efs7i7dkb4pnb599fabnbbb