Genetic and Diet-Induced Obesity Increased Intestinal Tumorigenesis in the Double Mutant Mouse Model Multiple Intestinal Neoplasia X Obese via Disturbed Glucose Regulation and Inflammation

We have studied how spontaneous or carcinogen-induced intestinal tumorigenesis was affected by genetic or diet-induced obesity in C57BL/6J-Apc (Min/+) X C57BL/6J-Lep (ob/+) mice. Obesity was induced by the obese (ob) mutation in the lep gene coding for the hormone leptin, or by a 45% fat diet. The e...

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Detalles Bibliográficos
Autores principales: Ngo, Ha Thi, Hetland, Ragna Bogen, Nygaard, Unni Cecilie, Steffensen, Inger-Lise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546984/
https://www.ncbi.nlm.nih.gov/pubmed/26347815
http://dx.doi.org/10.1155/2015/343479

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546984/
https://www.ncbi.nlm.nih.gov/pubmed/26347815
http://dx.doi.org/10.1155/2015/343479

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