Structural analysis of Anopheles midgut aminopeptidase N reveals a novel malaria transmission-blocking vaccine B-cell epitope

Mosquito-based malaria transmission-blocking vaccines (mTBVs) target midgut-surface antigens of the Plasmodium parasite's obligate vector, the Anopheles mosquito. The alanyl aminopeptidase N (AnAPN1) is the leading mTBV immunogen; however AnAPN1's role in Plasmodium infection of the mosqui...

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Detalles Bibliográficos
Autores principales: Atkinson, Sarah C., Armistead, Jennifer S., Mathias, Derrick K., Sandeu, Maurice M., Tao, Dingyin, Borhani-Dizaji, Nahid, Tarimo, Brian B., Morlais, Isabelle, Dinglasan, Rhoel R., Borg, Natalie A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547048/
https://www.ncbi.nlm.nih.gov/pubmed/26075520
http://dx.doi.org/10.1038/nsmb.3048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547048/
https://www.ncbi.nlm.nih.gov/pubmed/26075520
http://dx.doi.org/10.1038/nsmb.3048

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