Cargando…
Mild hypoxia in vivo regulates cardioprotective SUR2A: A role for Akt and LDH
High-altitude residents have lower mortality rates for ischaemic heart disease and this is ascribed to cardiac gene remodelling by chronic hypoxia. SUR2A is a cardioprotective ABC protein serving as a subunit of sarcolemmal ATP-sensitive K(+) channels. The purpose of this study was to determine whet...
Autores principales: | Mohammed Abdul, Khaja Shameem, Jovanović, Sofija, Du, Qingyou, Sukhodub, Andriy, Jovanović, Aleksandar |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Pub. Co
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547089/ https://www.ncbi.nlm.nih.gov/pubmed/25576887 http://dx.doi.org/10.1016/j.bbadis.2015.01.001 |
Ejemplares similares
-
Upregulation of cardioprotective SUR2A by sub-hypoxic drop in oxygen
por: Mohammed Abdul, Khaja Shameem, et al.
Publicado: (2014) -
A link between ATP and SUR2A: A novel mechanism explaining cardioprotection at high altitude()
por: Mohammed Abdul, Khaja Shameem, et al.
Publicado: (2015) -
Exposure to 15% oxygen in vivo up‐regulates cardioprotective SUR2A without affecting ERK1/2 and AKT: a crucial role for AMPK
por: Mohammed Abdul, Khaja Shameem, et al.
Publicado: (2017) -
A dual mechanism of cytoprotection afforded by M-LDH in embryonic heart H9C2 cells
por: Jovanović, Sofija, et al.
Publicado: (2009) -
M-LDH physically associated with sarcolemmal K(ATP) channels mediates cytoprotection in heart embryonic H9C2 cells
por: Jovanović, Sofija, et al.
Publicado: (2009)