Prefrontal dopamine regulates fear reinstatement through the downregulation of extinction circuits

Prevention of relapses is a major challenge in treating anxiety disorders. Fear reinstatement can cause relapse in spite of successful fear reduction through extinction-based exposure therapy. By utilising a contextual fear-conditioning task in mice, we found that reinstatement was accompanied by de...

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Detalles Bibliográficos
Autores principales: Hitora-Imamura, Natsuko, Miura, Yuki, Teshirogi, Chie, Ikegaya, Yuji, Matsuki, Norio, Nomura, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547090/
https://www.ncbi.nlm.nih.gov/pubmed/26226637
http://dx.doi.org/10.7554/eLife.08274

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547090/
https://www.ncbi.nlm.nih.gov/pubmed/26226637
http://dx.doi.org/10.7554/eLife.08274

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