mTOR signaling in mice with dysfunctional cardiac ryanodine receptor ion channel

Simultaneous substitution of three amino acid residues in the calmodulin binding domain (W3587A/L3591D/F3603A, ADA) of the cardiac ryanodine receptor ion channel (RyR2) impairs calmodulin inhibition of RyR2 and causes cardiac hypertrophy and early death of Ryr2(ADA/ADA) mice. To determine the physio...

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Detalles Bibliográficos
Autores principales: Huang, Tai-Qin, Zou, Min-Xu, Pasek, Daniel A, Meissner, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547478/
https://www.ncbi.nlm.nih.gov/pubmed/26312014
http://dx.doi.org/10.2147/JRLCR.S78410

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547478/
https://www.ncbi.nlm.nih.gov/pubmed/26312014
http://dx.doi.org/10.2147/JRLCR.S78410

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