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Autophagy dysfunction upregulates beta-amyloid peptides via enhancing the activity of γ-secretase complex
Numerous studies have shown that autophagy failure plays a critical role in the pathogenesis of Alzheimer’s disease, including increased expression of beta-amyloid (Aβ) protein and the dysfunction of Aβ clearance. To further evaluate the role of autophagy in Alzheimer’s disease, the present study wa...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Dove Medical Press
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547656/ https://www.ncbi.nlm.nih.gov/pubmed/26316755 http://dx.doi.org/10.2147/NDT.S84755 |