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Autophagy dysfunction upregulates beta-amyloid peptides via enhancing the activity of γ-secretase complex

Numerous studies have shown that autophagy failure plays a critical role in the pathogenesis of Alzheimer’s disease, including increased expression of beta-amyloid (Aβ) protein and the dysfunction of Aβ clearance. To further evaluate the role of autophagy in Alzheimer’s disease, the present study wa...

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Detalles Bibliográficos
Autores principales:	Cai, Zhiyou, Zhou, Yingjun, Liu, Zhou, Ke, Zunyu, Zhao, Bin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547656/ https://www.ncbi.nlm.nih.gov/pubmed/26316755 http://dx.doi.org/10.2147/NDT.S84755

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