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Tumor Suppressor WWOX Contributes to the Elimination of Tumorigenic Cells in Drosophila melanogaster

WWOX is a >1Mb gene spanning FRA16D Common Chromosomal Fragile Site, a region of DNA instability in cancer. Consequently, altered WWOX levels have been observed in a wide variety of cancers. In vitro studies have identified a large number and variety of potential roles for WWOX. Although its norm...

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Detalles Bibliográficos
Autores principales: O’Keefe, Louise V., Lee, Cheng Shoou, Choo, Amanda, Richards, Robert I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547717/
https://www.ncbi.nlm.nih.gov/pubmed/26302329
http://dx.doi.org/10.1371/journal.pone.0136356