Cargando…

Tumor Suppressor WWOX Contributes to the Elimination of Tumorigenic Cells in Drosophila melanogaster

WWOX is a >1Mb gene spanning FRA16D Common Chromosomal Fragile Site, a region of DNA instability in cancer. Consequently, altered WWOX levels have been observed in a wide variety of cancers. In vitro studies have identified a large number and variety of potential roles for WWOX. Although its norm...

Descripción completa

Detalles Bibliográficos
Autores principales:	O’Keefe, Louise V., Lee, Cheng Shoou, Choo, Amanda, Richards, Robert I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547717/ https://www.ncbi.nlm.nih.gov/pubmed/26302329 http://dx.doi.org/10.1371/journal.pone.0136356

Ejemplares similares

Molecular Biology of the WWOX Gene That Spans Chromosomal Fragile Site FRA16D
por: Lee, Cheng Shoou, et al.
Publicado: (2021)

Drosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen species
por: O'Keefe, Louise V., et al.
Publicado: (2011)

Pleiotropic tumor suppressor functions of WWOX antagonize metastasis
por: Khawaled, Saleh, et al.
Publicado: (2020)

Tumor Suppressor WWOX and p53 Alterations and Drug Resistance in Glioblastomas
por: Chiang, Ming-Fu, et al.
Publicado: (2013)

VOPP1 promotes breast tumorigenesis by interacting with the tumor suppressor WWOX
por: Bonin, Florian, et al.
Publicado: (2018)

Tumor Suppressor WWOX inhibits osteosarcoma metastasis by modulating RUNX2 function
por: Del Mare, Sara, et al.
Publicado: (2015)

Genetic and molecular analysis of six tumor suppressor genes in Drosophila melanogaster
por: Löffler, Thomas, et al.
Publicado: (1990)

Generation and Characterization of Mice Carrying a Conditional Allele of the Wwox Tumor Suppressor Gene
por: Ludes-Meyers, John H., et al.
Publicado: (2009)

In Memoriam: Shur-Tzu (Su) Chen, a pioneer in tumor suppressor WWOX for neuroscience
por: Chang, Nan-Shan
Publicado: (2015)

WWOX Tumor Suppressor Gene in Breast Cancer, a Historical Perspective and Future Directions
por: Pospiech, Karolina, et al.
Publicado: (2018)

PARTICLE triplexes cluster in the tumor suppressor WWOX and may extend throughout the human genome
por: O’Leary, Valerie Bríd, et al.
Publicado: (2017)

Molecular action of the l(2)gl tumor suppressor gene of Drosophila melanogaster.
por: Merz, R, et al.
Publicado: (1990)

Tumor suppressor WWOX binds to ΔNp63α and sensitizes cancer cells to chemotherapy
por: Salah, Z, et al.
Publicado: (2013)

Alternating expression levels of WWOX tumor suppressor and cancer-related genes in patients with bladder cancer
por: PŁUCIENNIK, ELŻBIETA, et al.
Publicado: (2014)

Complement C1q Activates Tumor Suppressor WWOX to Induce Apoptosis in Prostate Cancer Cells
por: Hong, Qunying, et al.
Publicado: (2009)

The CCR4-NOT complex is a tumor suppressor in Drosophila melanogaster eye cancer models
por: Vicente, Carmen, et al.
Publicado: (2018)

Loss of the Tumor Suppressor Pten Promotes Proliferation of Drosophila melanogaster Cells In Vitro and Gives Rise to Continuous Cell Lines
por: Justiniano, Steven E., et al.
Publicado: (2012)

TMEM207 hinders the tumour suppressor function of WWOX in oral squamous cell carcinoma
por: Bunai, Katsuaki, et al.
Publicado: (2017)

Impact of nuclear Piwi elimination on chromatin state in Drosophila melanogaster ovaries
por: Klenov, Mikhail S., et al.
Publicado: (2014)

The Complex Contributions of Genetics and Nutrition to Immunity in Drosophila melanogaster
por: Unckless, Robert L., et al.
Publicado: (2015)

Impact of decitabine on immunohistochemistry expression of the putative tumor suppressor genes FHIT, WWOX, FUS1 and PTEN in clinical tumor samples
por: Stewart, David J, et al.
Publicado: (2014)

Neonatal neuronal WWOX gene therapy rescues Wwox null phenotypes
por: Repudi, Srinivasarao, et al.
Publicado: (2021)

The supposed tumor suppressor gene WWOX is mutated in an early lethal microcephaly syndrome with epilepsy, growth retardation and retinal degeneration
por: Abdel-Salam, Ghada, et al.
Publicado: (2014)

Cancerous Protein Network That Inhibits the Tumor Suppressor Function of WW Domain-Containing Oxidoreductase (WWOX) by Aberrantly Expressed Molecules
por: Saigo, Chiemi, et al.
Publicado: (2018)

Loss of tumor suppressor WWOX accelerates pancreatic cancer development through promotion of TGFβ/BMP2 signaling
por: Husanie, Hussam, et al.
Publicado: (2022)

Molecular landscapes of glioblastoma cell lines revealed a group of patients that do not benefit from WWOX tumor suppressor expression
por: Kałuzińska-Kołat, Żaneta, et al.
Publicado: (2023)

G(o )contributes to olfactory reception in Drosophila melanogaster
por: Chatterjee, Abhishek, et al.
Publicado: (2009)

Ion Channel Contributions to Wing Development in Drosophila melanogaster
por: George, Laura Faith, et al.
Publicado: (2019)

Using Drosophila Models of Amyloid Toxicity to Study Autophagy in the Pathogenesis of Alzheimer's Disease
por: O'Keefe, Louise, et al.
Publicado: (2018)

Relative Effectiveness of Mating Success and Sperm Competition at Eliminating Deleterious Mutations in Drosophila melanogaster
por: Clark, Sean C. A., et al.
Publicado: (2012)

Drosophila Melanogaster
por: Wixon, Jo, et al.
Publicado: (2000)

WWOX Possesses N-Terminal Cell Surface-Exposed Epitopes WWOX(7-21) and WWOX(7-11) for Signaling Cancer Growth Suppression and Prevention In Vivo
por: Wang, Wan-Jen, et al.
Publicado: (2019)

MicroRNAs That Contribute to Coordinating the Immune Response in Drosophila melanogaster
por: Atilano, Magda L., et al.
Publicado: (2017)

Transposable elements contribute to the genomic response to insecticides in Drosophila melanogaster
por: Salces-Ortiz, Judit, et al.
Publicado: (2020)

Sleep contributes to preference for novel food odours in Drosophila melanogaster
por: Tanizawa, Fuminori, et al.
Publicado: (2021)

Inhibition of colorectal cancer genomic copy number alterations and chromosomal fragile site tumor suppressor FHIT and WWOX deletions by DNA mismatch repair
por: Jahid, Sohail, et al.
Publicado: (2017)

WWOX Loses the Ability to Regulate Oncogenic AP-2γ and Synergizes with Tumor Suppressor AP-2α in High-Grade Bladder Cancer
por: Kołat, Damian, et al.
Publicado: (2021)

The effect of gut microbiota elimination in Drosophila melanogaster: A how‐to guide for host–microbiota studies
por: Heys, Chloe, et al.
Publicado: (2018)

WWOX Phosphorylation, Signaling, and Role in Neurodegeneration
por: Liu, Chan-Chuan, et al.
Publicado: (2018)

WWOX loss activates aerobic glycolysis
por: Abu-Remaileh, Muhannad, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_pb18km7v9o42tuemjfh86ecllu