Cancer Cell Growth Is Differentially Affected by Constitutive Activation of NRF2 by KEAP1 Deletion and Pharmacological Activation of NRF2 by the Synthetic Triterpenoid, RTA 405

Synthetic triterpenoids are antioxidant inflammation modulators (AIMs) that exhibit broad anticancer activity. AIMs bind to KEAP1 and inhibit its ability to promote NRF2 degradation. As a result, NRF2 increases transcription of genes that restore redox balance and reduce inflammation. AIMs inhibit t...

Descripción completa

Detalles Bibliográficos
Autores principales: Probst, Brandon L., McCauley, Lyndsey, Trevino, Isaac, Wigley, W. Christian, Ferguson, Deborah A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547720/
https://www.ncbi.nlm.nih.gov/pubmed/26301506
http://dx.doi.org/10.1371/journal.pone.0135257

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547720/
https://www.ncbi.nlm.nih.gov/pubmed/26301506
http://dx.doi.org/10.1371/journal.pone.0135257

Ejemplares similares