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Structure of silent transcription intervals and noise characteristics of mammalian genes

Mammalian transcription occurs stochastically in short bursts interspersed by silent intervals showing a refractory period. However, the underlying processes and consequences on fluctuations in gene products are poorly understood. Here, we use single allele time-lapse recordings in mouse cells to id...

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Detalles Bibliográficos
Autores principales: Zoller, Benjamin, Nicolas, Damien, Molina, Nacho, Naef, Felix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547851/
https://www.ncbi.nlm.nih.gov/pubmed/26215071
http://dx.doi.org/10.15252/msb.20156257