The CDKN1B-RB1-E2F1 pathway protects mouse spermatogonial stem cells from genomic damage

Spermatogonial stem cells (SSCs) undergo self-renewal divisions to provide the foundation for spermatogenesis. Although Rb1 deficiency is reportedly essential for SSC self-renewal, its mechanism has remained unknown. Here we report that Rb1 is critical for cell cycle progression and protection of SS...

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Detalles Bibliográficos
Autores principales: TANAKA, Takashi, KANATSU-SHINOHARA, Mito, SHINOHARA, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Society for Reproduction and Development 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547988/
https://www.ncbi.nlm.nih.gov/pubmed/25959802
http://dx.doi.org/10.1262/jrd.2015-027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547988/
https://www.ncbi.nlm.nih.gov/pubmed/25959802
http://dx.doi.org/10.1262/jrd.2015-027

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