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Production of a mouse strain with impaired glucose tolerance by systemic heterozygous knockout of the glucokinase gene and its feasibility as a prediabetes model
Exon II of glucokinase (Gk) was deleted to produce a systemic heterozygous Gk knockout (Gk(+/−)) mouse. The relative expression levels of Gk in the heart, lung, liver, stomach, and pancreas in Gk(+/−) mice ranged from 0.41–0.68 versus that in wild (Gk(+/+)) mice. On the other hand, its expression le...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Japanese Association for Laboratory Animal Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547996/ https://www.ncbi.nlm.nih.gov/pubmed/25765873 http://dx.doi.org/10.1538/expanim.14-0089 |