Cargando…

UCP-3 uncoupling protein confers hypoxia resistance to renal epithelial cells and is upregulated in renal cell carcinoma

Tumor cells can adapt to a hostile environment with reduced oxygen supply. The present study aimed to identify mechanisms that confer hypoxia resistance. Partially hypoxia/reoxygenation (H/R)-resistant proximal tubular (PT) cells were selected by exposing PT cultures to repetitive cycles of H/R. The...

Descripción completa

Detalles Bibliográficos
Autores principales:	Braun, Norbert, Klumpp, Dominik, Hennenlotter, Jörg, Bedke, Jens, Duranton, Christophe, Bleif, Martin, Huber, Stephan M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548255/ https://www.ncbi.nlm.nih.gov/pubmed/26304588 http://dx.doi.org/10.1038/srep13450

Ejemplares similares

Differential Expression and Clinical Relevance of C-X-C Motif Chemokine Receptor 4 (CXCR4) in Renal Cell Carcinomas, Benign Renal Tumors, and Metastases
por: Maas, Moritz, et al.
Publicado: (2023)

Relationships between Uncoupling Protein Genes UCP1, UCP2 and UCP3 and Irisin Levels in Residents of the Coldest Region of Siberia
por: Nikanorova, Alena A., et al.
Publicado: (2022)

Nicotinamide‐N‐methyltransferase is a promising metabolic drug target for primary and metastatic clear cell renal cell carcinoma
por: Reustle, Anna, et al.
Publicado: (2022)

MCT4 surpasses the prognostic relevance of the ancillary protein CD147 in clear cell renal cell carcinoma
por: Fisel, Pascale, et al.
Publicado: (2015)

Clinical utility of the S3-score for molecular prediction of outcome in non-metastatic and metastatic clear cell renal cell carcinoma
por: Büttner, Florian, et al.
Publicado: (2018)

New Aspects of Mitochondrial Uncoupling Proteins (UCPs) and Their Roles in Tumorigenesis
por: Robbins, Delira, et al.
Publicado: (2011)

Association of uncoupling protein (Ucp) gene polymorphisms with cardiometabolic diseases
por: Pravednikova, Anna E., et al.
Publicado: (2020)

Molecular determinants of inhibition of UCP1-mediated respiratory uncoupling
por: Gagelin, Antoine, et al.
Publicado: (2023)

Brain Overexpression of Uncoupling Protein-2 (UCP2) Delays Renal Damage and Stroke Occurrence in Stroke-Prone Spontaneously Hypertensive Rats
por: Busceti, Carla L., et al.
Publicado: (2020)

Characterization of Genetic Heterogeneity in Recurrent Metastases of Renal Cell Carcinoma
por: Sauter-Meyerhoff, Carolin, et al.
Publicado: (2021)

Unveiling the Role of the Proton Gateway, Uncoupling Proteins (UCPs), in Cancer Cachexia
por: Joshi, Mit, et al.
Publicado: (2023)

MiR-99b-5p expression and response to tyrosine kinase inhibitor treatment in clear cell renal cell carcinoma patients
por: Lukamowicz-Rajska, Magdalena, et al.
Publicado: (2016)

Expressions of mRNA and encoded proteins of mitochondrial uncoupling protein genes (UCP1, UCP2, and UCP3) in epicardial and mediastinal adipose tissue and associations with coronary artery disease
por: Huesca-Gómez, Claudia, et al.
Publicado: (2023)

Uncoupling Protein-4 (UCP4) Increases ATP Supply by Interacting with Mitochondrial Complex II in Neuroblastoma Cells
por: Ho, Philip Wing-Lok, et al.
Publicado: (2012)

Mitochondrial Uncoupling Protein-2 (UCP2) Mediates Leptin Protection Against MPP(+) Toxicity in Neuronal Cells
por: Ho, Philip Wing-Lok, et al.
Publicado: (2009)

Tumour response in metastatic renal cell carcinoma treated with tyrosine kinase inhibitors – assessment of intra-tumour heterogeneity
por: Stühler, Viktoria, et al.
Publicado: (2016)

Methylomes of renal cell lines and tumors or metastases differ significantly with impact on pharmacogenes
por: Winter, Stefan, et al.
Publicado: (2016)

Increased UCP1 expression in the perirenal adipose tissue of patients with renal cell carcinoma
por: Li, Xueqin, et al.
Publicado: (2019)

Leucine Deprivation Decreases Fat Mass by Stimulation of Lipolysis in White Adipose Tissue and Upregulation of Uncoupling Protein 1 (UCP1) in Brown Adipose Tissue
por: Cheng, Ying, et al.
Publicado: (2010)

Further Support to the Uncoupling-to-Survive Theory: The Genetic Variation of Human UCP Genes Is Associated with Longevity
por: Rose, Giuseppina, et al.
Publicado: (2011)

Loss of UCP2 Attenuates Mitochondrial Dysfunction without Altering ROS Production and Uncoupling Activity
por: Kukat, Alexandra, et al.
Publicado: (2014)

A Rare Case of Synchronous Renal Cell Carcinoma of the Bladder Presenting With Gross Hematuria
por: Kruck, Stephan, et al.
Publicado: (2013)

Upregulation of UCP2 in beta-cells confers partial protection against both oxidative stress and glucotoxicity
por: Li, Ning, et al.
Publicado: (2017)

Real world data on IO-based therapy for metastatic renal cell carcinoma
por: Stühler, Viktoria, et al.
Publicado: (2022)

Clonal expansion of renal cell carcinoma-infiltrating T lymphocytes
por: Sittig, Simone P, et al.
Publicado: (2013)

Population Genetic Analysis of the Uncoupling Proteins Supports a Role for UCP3 in Human Cold Resistance
por: Hancock, Angela M., et al.
Publicado: (2011)

Antagonistic effect of TNF-alpha and insulin on uncoupling protein 2 (UCP-2) expression and vascular damage
por: Gómez-Hernández, Almudena, et al.
Publicado: (2014)

In the Early Stages of Diabetes, Rat Retinal Mitochondria Undergo Mild Uncoupling due to UCP2 Activity
por: Osorio-Paz, Ixchel, et al.
Publicado: (2015)

Transcriptome Response Signatures Associated with the Overexpression of a Mitochondrial Uncoupling Protein (AtUCP1) in Tobacco
por: Laitz, Alessandra Vasconcellos Nunes, et al.
Publicado: (2015)

Systems biology reveals uncoupling beyond UCP1 in human white fat-derived beige adipocytes
por: Nyman, Elin, et al.
Publicado: (2017)

Association of Uncoupling Protein 1 (UCP1) gene polymorphism with obesity: a case-control study
por: Chathoth, Shahanas, et al.
Publicado: (2018)

Human neuronal uncoupling proteins 4 and 5 (UCP4 and UCP5): structural properties, regulation, and physiological role in protection against oxidative stress and mitochondrial dysfunction
por: Ramsden, David B, et al.
Publicado: (2012)

Mitochondrial Uncoupling Proteins (UCP1-UCP3) and Adenine Nucleotide Translocase (ANT1) Enhance the Protonophoric Action of 2,4-Dinitrophenol in Mitochondria and Planar Bilayer Membranes
por: Žuna, Kristina, et al.
Publicado: (2021)

Uncoupling protein 1-driven Cre (Ucp1-Cre) is expressed in the epithelial cells of mammary glands and various non-adipose tissues
por: Kim, Kyungchan, et al.
Publicado: (2023)

Checkpoint modulation - A new way to direct the immune system against renal cell carcinoma
por: Bedke, Jens, et al.
Publicado: (2015)

Increased uncoupling protein (UCP) activity in Drosophila insulin-producing neurons attenuates insulin signaling and extends lifespan
por: Fridell, Yih-Woei C., et al.
Publicado: (2009)

Overexpression of mitochondrial uncoupling protein 1 (UCP1) induces a hypoxic response in Nicotiana tabacum leaves
por: Barreto, Pedro, et al.
Publicado: (2016)

Role of mitochondrial uncoupling protein-2 (UCP2) in higher brain functions, neuronal plasticity and network oscillation
por: Hermes, Gretchen, et al.
Publicado: (2016)

Uncoupling Protein, UCP-4 May Be Involved in Neuronal Defects During Aging and Resistance to Pathogens in Caenorhabditis elegans
por: Cho, Injeong, et al.
Publicado: (2016)

Uncoupling protein 4 (UCP4) gene variability in neurodegenerative disorders: further evidence of association in Frontotemporal dementia
por: Montesanto, Alberto, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_2m449rek98b7in1mj6fkfip3sl