The influence of allosteric modulators and transmembrane mutations on desensitisation and activation of α7 nicotinic acetylcholine receptors

Acetylcholine activates nicotinic acetylcholine receptors (nAChRs) by binding at an extracellular orthosteric site. Previous studies have described several positive allosteric modulators (PAMs) that are selective for homomeric α7 nAChRs. These include type I PAMs, which exert little or no effect on...

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Detalles Bibliográficos
Autores principales: Chatzidaki, Anna, D'Oyley, Jarryl M., Gill-Thind, JasKiran K., Sheppard, Tom D., Millar, Neil S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pergamon Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548482/
https://www.ncbi.nlm.nih.gov/pubmed/25998276
http://dx.doi.org/10.1016/j.neuropharm.2015.05.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548482/
https://www.ncbi.nlm.nih.gov/pubmed/25998276
http://dx.doi.org/10.1016/j.neuropharm.2015.05.006

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