The Contribution of Missense Mutations in Core and Rim Residues of Protein–Protein Interfaces to Human Disease

Missense mutations at protein–protein interaction sites, called interfaces, are important contributors to human disease. Interfaces are non-uniform surface areas characterized by two main regions, “core” and “rim”, which differ in terms of evolutionary conservation and physicochemical properties. Mo...

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Detalles Bibliográficos
Autores principales: David, Alessia, Sternberg, Michael J.E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548493/
https://www.ncbi.nlm.nih.gov/pubmed/26173036
http://dx.doi.org/10.1016/j.jmb.2015.07.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548493/
https://www.ncbi.nlm.nih.gov/pubmed/26173036
http://dx.doi.org/10.1016/j.jmb.2015.07.004

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