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The Contribution of Missense Mutations in Core and Rim Residues of Protein–Protein Interfaces to Human Disease
Missense mutations at protein–protein interaction sites, called interfaces, are important contributors to human disease. Interfaces are non-uniform surface areas characterized by two main regions, “core” and “rim”, which differ in terms of evolutionary conservation and physicochemical properties. Mo...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548493/ https://www.ncbi.nlm.nih.gov/pubmed/26173036 http://dx.doi.org/10.1016/j.jmb.2015.07.004 |