Cargando…

Senescent Vascular Smooth Muscle Cells Drive Inflammation Through an Interleukin-1α–Dependent Senescence-Associated Secretory Phenotype

Vascular smooth muscle cells (VSMCs) that become senescent are both present within atherosclerotic plaques and thought to be important to the disease process. However, senescent VSMCs are generally considered to only contribute through inaction, with failure to proliferate resulting in VSMC- and col...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gardner, Sarah E., Humphry, Melanie, Bennett, Martin R., Clarke, Murray C.H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2015
Materias:	Basic Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548545/ https://www.ncbi.nlm.nih.gov/pubmed/26139463 http://dx.doi.org/10.1161/ATVBAHA.115.305896

Ejemplares similares

IL‐1α cleavage by inflammatory caspases of the noncanonical inflammasome controls the senescence‐associated secretory phenotype
por: Wiggins, Kimberley A., et al.
Publicado: (2019)

Cell senescence, the senescence-associated secretory phenotype, and cancers
por: Langhi Prata, Larissa G. P., et al.
Publicado: (2023)

Thrombin-activated interleukin-1α drives atherogenesis, but also promotes vascular smooth muscle cell proliferation and collagen production
por: Burzynski, Laura C, et al.
Publicado: (2023)

Senescence utilises inflammatory caspases to drive SASP
por: Wiggins, Kimberley A., et al.
Publicado: (2019)

Cellular senescence, senescence-associated secretory phenotype, and chronic kidney disease
por: Wang, Wen-Juan, et al.
Publicado: (2017)

Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis
por: Grootaert, Mandy OJ, et al.
Publicado: (2015)

Intracellular Interleukin-1 Receptor 2 Binding Prevents Cleavage and Activity of Interleukin-1α, Controlling Necrosis-Induced Sterile Inflammation
por: Zheng, Yue, et al.
Publicado: (2013)

Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype
por: Kumari, Ruchi, et al.
Publicado: (2021)

The microRNA-34a-Induced Senescence-Associated Secretory Phenotype (SASP) Favors Vascular Smooth Muscle Cells Calcification
por: Zuccolo, Estella, et al.
Publicado: (2020)

Senescence-activated enhancer landscape orchestrates the senescence-associated secretory phenotype in murine fibroblasts
por: Guan, Yiting, et al.
Publicado: (2020)

Immunotherapeutic approach to reduce senescent cells and alleviate senescence‐associated secretory phenotype in mice
por: Shrestha, Niraj, et al.
Publicado: (2023)

In vitro and in vivo effects of zoledronic acid on senescence and senescence-associated secretory phenotype markers
por: Samakkarnthai, Parinya, et al.
Publicado: (2023)

MLL1 is essential for the senescence-associated secretory phenotype
por: Capell, Brian C., et al.
Publicado: (2016)

The Role of Senescence-Associated Secretory Phenotype in Bone Loss
por: Zhu, Runjiu, et al.
Publicado: (2022)

The senescence-associated secretory phenotype induces neuroendocrine transdifferentiation
por: Huna, Anda, et al.
Publicado: (2023)

Senescence in Vascular Smooth Muscle Cells and Atherosclerosis
por: Zha, Yiwen, et al.
Publicado: (2022)

A model of the onset of the senescence associated secretory phenotype after DNA damage induced senescence
por: Meyer, Patrick, et al.
Publicado: (2017)

IFN-γ and TNF Induce Senescence and a Distinct Senescence-Associated Secretory Phenotype in Melanoma
por: Homann, Lorenzo, et al.
Publicado: (2022)

Ceria Nanoparticles Alleviated Osteoarthritis through Attenuating Senescence and Senescence-Associated Secretory Phenotype in Synoviocytes
por: Ren, Xunshan, et al.
Publicado: (2023)

Colchicine Protects against Ethanol-Induced Senescence and Senescence-Associated Secretory Phenotype in Endothelial Cells
por: Zhou, Huakang, et al.
Publicado: (2023)

NF90 coordinately represses the senescence-associated secretory phenotype
por: Tominaga-Yamanaka, Kumiko, et al.
Publicado: (2012)

HMGB2 holds the key to the senescence-associated secretory phenotype
por: Guerrero, Ana, et al.
Publicado: (2016)

Suppression of p16 alleviates the senescence-associated secretory phenotype
por: Buj, Raquel, et al.
Publicado: (2021)

From cell senescence to age-related diseases: differential mechanisms of action of senescence-associated secretory phenotypes
por: Byun, Hae-Ok, et al.
Publicado: (2015)

Impact of senescence‐associated secretory phenotype and its potential as a therapeutic target for senescence‐associated diseases
por: Watanabe, Sugiko, et al.
Publicado: (2017)

Cellular senescence and senescence‐associated secretory phenotype via the cGAS‐STING signaling pathway in cancer
por: Loo, Tze Mun, et al.
Publicado: (2019)

The impact of cellular senescence and senescence‑associated secretory phenotype in cancer‑associated fibroblasts on the malignancy of pancreatic cancer
por: Higashiguchi, Masaya, et al.
Publicado: (2023)

Endothelial progeria induces adipose tissue senescence and impairs insulin sensitivity through senescence associated secretory phenotype
por: Barinda, Agian Jeffilano, et al.
Publicado: (2020)

Impacts of Telomeric Length, Chronic Hypoxia, Senescence, and Senescence-Associated Secretory Phenotype on the Development of Thoracic Aortic Aneurysm
por: Aschacher, Thomas, et al.
Publicado: (2022)

Senescent Endothelial Cells Sustain Their Senescence-Associated Secretory Phenotype (SASP) through Enhanced Fatty Acid Oxidation
por: Giuliani, Angelica, et al.
Publicado: (2023)

Exosomes as Emerging Pro-Tumorigenic Mediators of the Senescence-Associated Secretory Phenotype
por: Jakhar, Rekha, et al.
Publicado: (2019)

The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration
por: Ritschka, Birgit, et al.
Publicado: (2017)

Tumor stroma with senescence-associated secretory phenotype in steatohepatitic hepatocellular carcinoma
por: Lee, Jee San, et al.
Publicado: (2017)

The bright and dark side of extracellular vesicles in the senescence-associated secretory phenotype
por: Wallis, Ryan, et al.
Publicado: (2020)

Extracellular Nicotinamide Phosphoribosyltransferase Is a Component of the Senescence-Associated Secretory Phenotype
por: Kuehnemann, Chisaka, et al.
Publicado: (2022)

Senescence-associated secretory phenotype and its impact on oral immune homeostasis
por: Yue, Ziqi, et al.
Publicado: (2022)

Mannose-Binding Lectin Drives Platelet Inflammatory Phenotype and Vascular Damage After Cerebral Ischemia in Mice via IL (Interleukin)-1α
por: Orsini, Franca, et al.
Publicado: (2018)

312 Metabolomics Approach to Cellular Senescence: Characterizing the Secretory Phenotype and Metabolism of Irradiation-Induced Senescent Human Pre- Adipocytes
por: Ortiz-Correa, Zinnarky Kiani, et al.
Publicado: (2023)

S100A13 promotes senescence-associated secretory phenotype and cellular senescence via modulation of non-classical secretion of IL-1α
por: Su, Yuanyuan, et al.
Publicado: (2019)

Senescence-associated secretory phenotype favors the emergence of cancer stem-like cells
por: Cahu, J, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_vnlu9lehrmr1ongajnn2vr0h7o