Anti-cancer DNA Intercalators cause p53 Dependent Mitochondrial DNA Nucleoid Re-modelling

Many anti-cancer drugs, such doxorubicin (DXR), intercalate into nuclear DNA of cancer cells thereby inhibiting their growth. However, it is not well understood how such drugs interact with mitochondrial DNA (mtDNA). Using cell and molecular studies of cultured cells we show that DXR and other DNA i...

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Detalles Bibliográficos
Autores principales: Ashley, Neil, Poulton, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548715/
https://www.ncbi.nlm.nih.gov/pubmed/19684617
http://dx.doi.org/10.1038/onc.2009.242

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548715/
https://www.ncbi.nlm.nih.gov/pubmed/19684617
http://dx.doi.org/10.1038/onc.2009.242

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