NF-κB1 p105 suppresses lung tumorigenesis through the Tpl2 kinase but independently of its NF-κB function

NF-κB is generally believed to be pro-tumorigenic. Here, we report a tumor-suppressive function for NF-κB1, the prototypical member of NF-κB. While NF-κB1 down-regulation is associated with high lung cancer risk in humans and poor patient survival, NF-κB1 deficient mice are more vulnerable to lung t...

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Detalles Bibliográficos
Autores principales: Sun, Fan, Qu, Zhaoxia, Xiao, Yadong, Zhou, Jingjiao, Burns, Timothy F., Stabile, Laura P., Siegfried, Jill M., Xiao, Gutian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548811/
https://www.ncbi.nlm.nih.gov/pubmed/26300007
http://dx.doi.org/10.1038/onc.2015.299

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548811/
https://www.ncbi.nlm.nih.gov/pubmed/26300007
http://dx.doi.org/10.1038/onc.2015.299

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