Coevolutionary analyses require phylogenetically deep alignments and better null models to accurately detect inter-protein contacts within and between species

BACKGROUND: When biomolecules physically interact, natural selection operates on them jointly. Contacting positions in protein and RNA structures exhibit correlated patterns of sequence evolution due to constraints imposed by the interaction, and molecular arms races can develop between interacting...

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Detalles Bibliográficos
Autores principales: Avila-Herrera, Aram, Pollard, Katherine S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549020/
https://www.ncbi.nlm.nih.gov/pubmed/26303588
http://dx.doi.org/10.1186/s12859-015-0677-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549020/
https://www.ncbi.nlm.nih.gov/pubmed/26303588
http://dx.doi.org/10.1186/s12859-015-0677-y

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