Targeting procaspase-3 with WF-208, a novel PAC-1 derivative, causes selective cancer cell apoptosis

Caspase-3 is a critical effector caspase in apoptosis cascade, and is often over-expressed in many cancer tissues. The first synthesized procaspase-3 activator, PAC-1, induces cancer cell apoptosis and exhibits antitumour activity in murine xenograft models. To identify more potent procaspase-3 acti...

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Detalles Bibliográficos
Autores principales: Wang, Fangyang, Liu, Yajing, Wang, Lihui, Yang, Jingyu, Zhao, Yanfang, Wang, Nannan, Cao, Qi, Gong, Ping, Wu, Chunfu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549042/
https://www.ncbi.nlm.nih.gov/pubmed/25754465
http://dx.doi.org/10.1111/jcmm.12566

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549042/
https://www.ncbi.nlm.nih.gov/pubmed/25754465
http://dx.doi.org/10.1111/jcmm.12566

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