Detection of Ultra-Rare Mitochondrial Mutations in Breast Stem Cells by Duplex Sequencing

Long-lived adult stem cells could accumulate non-repaired DNA damage or mutations that increase the risk of tumor formation. To date, studies on mutations in stem cells have concentrated on clonal (homoplasmic) mutations and have not focused on rarely occurring stochastic mutations that may accumula...

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Detalles Bibliográficos
Autores principales: Ahn, Eun Hyun, Hirohata, Kensen, Kohrn, Brendan F., Fox, Edward J., Chang, Chia-Cheng, Loeb, Lawrence A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549069/
https://www.ncbi.nlm.nih.gov/pubmed/26305705
http://dx.doi.org/10.1371/journal.pone.0136216

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549069/
https://www.ncbi.nlm.nih.gov/pubmed/26305705
http://dx.doi.org/10.1371/journal.pone.0136216

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