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Detection of Ultra-Rare Mitochondrial Mutations in Breast Stem Cells by Duplex Sequencing
Long-lived adult stem cells could accumulate non-repaired DNA damage or mutations that increase the risk of tumor formation. To date, studies on mutations in stem cells have concentrated on clonal (homoplasmic) mutations and have not focused on rarely occurring stochastic mutations that may accumula...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549069/ https://www.ncbi.nlm.nih.gov/pubmed/26305705 http://dx.doi.org/10.1371/journal.pone.0136216 |