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Selective repression of RET proto-oncogene in medullary thyroid carcinoma by a natural alkaloid berberine
BACKGROUND: The gain-of-function mutation of the RET proto-oncogene, which encodes a receptor tyrosine kinase, is strongly associated with the development of several medullary thyroid carcinomas (MTCs). Thus, the RET protein has been explored as an excellent target for progressive and advanced MTC....
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549123/ https://www.ncbi.nlm.nih.gov/pubmed/26307103 http://dx.doi.org/10.1186/s12885-015-1610-5 |