The Broad Anti-AML Activity of the CD33/CD3 BiTE Antibody Construct, AMG 330, Is Impacted by Disease Stage and Risk

The CD33/CD3-bispecific T-cell engaging (BiTE) antibody construct, AMG 330, potently lyses CD33+ leukemic cells in vitro. Using specimens from 41 patients with acute myeloid leukemia (AML), we studied the factors that might contribute to clinical response or resistance. For this purpose, thawed aliq...

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Detalles Bibliográficos
Autores principales: Harrington, Kimberly H., Gudgeon, Chelsea J., Laszlo, George S., Newhall, Kathryn J., Sinclair, Angus M., Frankel, Stanley R., Kischel, Roman, Chen, Guang, Walter, Roland B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549148/
https://www.ncbi.nlm.nih.gov/pubmed/26305211
http://dx.doi.org/10.1371/journal.pone.0135945

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549148/
https://www.ncbi.nlm.nih.gov/pubmed/26305211
http://dx.doi.org/10.1371/journal.pone.0135945

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