Cargando…

Rapamycin improves motor function, reduces 4-hydroxynonenal adducted protein in brain, and attenuates synaptic injury in a mouse model of synucleinopathy

BACKGROUND: Synucleinopathy is any of a group of age-related neurodegenerative disorders including Parkinson's disease, multiple system atrophy, and dementia with Lewy Bodies, which is characterized by α-synuclein inclusions and parkinsonian motor deficits affecting millions of patients worldwi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bai, Xiang, Wey, Margaret Chia-Ying, Fernandez, Elizabeth, Hart, Matthew J., Gelfond, Jonathan, Bokov, Alex F., Rani, Sheela, Strong, Randy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Co-Action Publishing 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549373/ https://www.ncbi.nlm.nih.gov/pubmed/26306821 http://dx.doi.org/10.3402/pba.v5.28743

Ejemplares similares

Activation of proinflammatory signaling by 4-hydroxynonenal-Src adducts in aged kidneys
por: Jang, Eun Ji, et al.
Publicado: (2016)

Protein-Selective Capture to Analyze Electrophile Adduction of Hsp90 by 4-Hydroxynonenal
por: Connor, Rebecca E., et al.
Publicado: (2011)

The 4-Hydroxynonenal–Protein Adducts and Their Biological Relevance: Are Some Proteins Preferred Targets?
por: Milkovic, Lidija, et al.
Publicado: (2023)

Impaired aldehyde detoxification exacerbates motor deficits in an alpha‐synuclein mouse model of Parkinson's disease
por: Martinez, Paul Anthony, et al.
Publicado: (2023)

Neurochemical and motor changes in mice with combined mutations linked to Parkinson’s disease
por: Bai, Xiang, et al.
Publicado: (2017)

Circulating levels of linoleic acid and HDL-cholesterol are major determinants of 4-hydroxynonenal protein adducts in patients with heart failure()
por: Asselin, Caroline, et al.
Publicado: (2013)

Colonic expression of glutathione S-transferase alpha 4 and 4-hydroxynonenal adducts is correlated with the pathology of murine colitis-associated cancer
por: Ma, Chunhua, et al.
Publicado: (2023)

Chemistry and Biology of DNA Containing 1,N(2)-Deoxyguanosine Adducts of the α,β-Unsaturated Aldehydes Acrolein, Crotonaldehyde, and 4-Hydroxynonenal
por: Minko, Irina G., et al.
Publicado: (2009)

Heme-Iron-Induced Production of 4-Hydroxynonenal in Intestinal Lumen May Have Extra-Intestinal Consequences Through Protein-Adduct Formation
por: Keller, Julia, et al.
Publicado: (2020)

Neurodegeneration and Motor Dysfunction in Mice Lacking Cytosolic and Mitochondrial Aldehyde Dehydrogenases: Implications for Parkinson's Disease
por: Wey, Margaret Chia-Ying, et al.
Publicado: (2012)

Combined treatment of rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver
por: Fok, Wilson C, et al.
Publicado: (2014)

The Oxidant Role of 4-Hydroxynonenal in Corneal Epithelium
por: Chen, Longlong, et al.
Publicado: (2015)

Loss of tau expression attenuates neurodegeneration associated with α-synucleinopathy
por: Vermilyea, Scott C., et al.
Publicado: (2022)

Serum 4-hydroxynonenal associates with the recurrence of patients with primary cerebral infarction
por: Liu, Xingliang, et al.
Publicado: (2022)

Rapamycin extends life span of Rb1(+/−) mice by inhibiting neuroendocrine tumors
por: Livi, Carolina B., et al.
Publicado: (2013)

Estrogen-related receptor gamma regulates mitochondrial and synaptic genes and modulates vulnerability to synucleinopathy
por: Fox, S. N., et al.
Publicado: (2022)

Synaptic mechanisms underlying onset and progression of memory deficits caused by hippocampal and midbrain synucleinopathy
por: Iemolo, Attilio, et al.
Publicado: (2023)

miR-101a-3p Impairs Synaptic Plasticity and Contributes to Synucleinopathy
por: Xylaki, Mary, et al.
Publicado: (2023)

Replication Bypass of the trans-4-Hydroxynonenal-Derived (6S,8R,11S)-1,N(2)-Deoxyguanosine DNA Adduct by the Sulfolobus solfataricus DNA Polymerase IV
por: Banerjee, Surajit, et al.
Publicado: (2012)

4-Hydroxyhexenal- and 4-Hydroxynonenal-Modified Proteins in Pterygia
por: Sano, Ichiya, et al.
Publicado: (2013)

Expression of 4-hydroxynonenal in esophageal squamous cell carcinoma
por: Zhang, Ying, et al.
Publicado: (2017)

Protein Susceptibility to Peroxidation by 4-Hydroxynonenal in Hereditary Hemochromatosis
por: Sánchez-Jaut, Sandra, et al.
Publicado: (2023)

The Stereochemistry of trans-4-Hydroxynonenal-Derived Exocyclic 1,N(2)-2′-Deoxyguanosine Adducts Modulates Formation of Interstrand Cross-Links in the 5′-CpG-3′ Sequence
por: Huang, Hai, et al.
Publicado: (2008)

Tau is required for progressive synaptic and memory deficits in a transgenic mouse model of α-synucleinopathy
por: Singh, Balvindar, et al.
Publicado: (2019)

Rearrangement of the (6S,8R,11S) and (6R,8S,11R) Exocyclic 1,N(2)-Deoxyguanosine Adducts of trans-4-Hydroxynonenal to N(2)-Deoxyguanosine Cyclic Hemiacetal Adducts When Placed Complementary to Cytosine in Duplex DNA
por: Huang, Hai, et al.
Publicado: (2008)

Chemical disaggregation of alpha-synuclein fibrils as a therapy for synucleinopathies
por: Wu, Shenjie, et al.
Publicado: (2023)

Gaucher Disease and the Synucleinopathies
por: Hruska, Kathleen S., et al.
Publicado: (2006)

The Synucleinopathies: Twenty Years On
por: Goedert, Michel, et al.
Publicado: (2017)

Surgical Management of Synucleinopathies
por: Sriram, Sai, et al.
Publicado: (2022)

Pleiotropic effects of 4-hydroxynonenal on oxidative burst and phagocytosis in neutrophils
por: Chacko, Balu K., et al.
Publicado: (2016)

Lipid peroxidation in osteoarthritis: focusing on 4-hydroxynonenal, malondialdehyde, and ferroptosis
por: Zhang, Xiong, et al.
Publicado: (2023)

Implication of the cooking oil-peroxidation product “hydroxynonenal” for Alzheimer’s disease
por: Yamashima, Tetsumori, et al.
Publicado: (2023)

Alpha-synuclein in Parkinson’s disease and other synucleinopathies: from overt neurodegeneration back to early synaptic dysfunction
por: Calabresi, Paolo, et al.
Publicado: (2023)

Health Effects of Long-Term Rapamycin Treatment: The Impact on Mouse Health of Enteric Rapamycin Treatment from Four Months of Age throughout Life
por: Fischer, Kathleen E., et al.
Publicado: (2015)

Parkin Deficiency Delays Motor Decline and Disease Manifestation in a Mouse Model of Synucleinopathy
por: Fournier, Margot, et al.
Publicado: (2009)

Transient exposure to rotenone causes degeneration and progressive parkinsonian motor deficits, neuroinflammation, and synucleinopathy
por: Van Laar, Amber D., et al.
Publicado: (2023)

Adaptations to chronic rapamycin in mice
por: Dodds, Sherry G., et al.
Publicado: (2016)

Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits
por: Majumder, Smita, et al.
Publicado: (2011)

Hydroxynonenal causes Langerhans cell degeneration in the pancreas of Japanese macaque monkeys
por: Boontem, Piyakarn, et al.
Publicado: (2021)

Hydroxynonenal Causes Hepatocyte Death by Disrupting Lysosomal Integrity in Nonalcoholic Steatohepatitis
por: Seike, Takuya, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_rgiel3nbncv3omsstimov3kt6h