A distinct three-helix centipede toxin SSD609 inhibits I(ks) channels by interacting with the KCNE1 auxiliary subunit

KCNE1 is a single-span transmembrane auxiliary protein that modulates the voltage-gated potassium channel KCNQ1. The KCNQ1/KCNE1 complex in cardiomyocytes exhibited slow activated potassium (I(ks)) currents. Recently, a novel 47-residue polypeptide toxin SSD609 was purified from Scolopendra subspini...

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Detalles Bibliográficos
Autores principales: Sun, Peibei, Wu, Fangming, Wen, Ming, Yang, Xingwang, Wang, Chenyang, Li, Yiming, He, Shufang, Zhang, Longhua, Zhang, Yun, Tian, Changlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549624/
https://www.ncbi.nlm.nih.gov/pubmed/26307551
http://dx.doi.org/10.1038/srep13399

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549624/
https://www.ncbi.nlm.nih.gov/pubmed/26307551
http://dx.doi.org/10.1038/srep13399

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