The Neuraminidase Stalk Deletion Serves as Major Virulence Determinant of H5N1 Highly Pathogenic Avian Influenza Viruses in Chicken

Highly pathogenic avian influenza viruses (HPAIV) cause devastating losses in gallinaceous poultry world-wide and raised concerns of a novel pandemic. HPAIV develop from low-pathogenic precursors by acquisition of a polybasic HA cleavage site (HACS), the prime virulence determinant. Beside that HACS...

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Detalles Bibliográficos
Autores principales: Stech, Olga, Veits, Jutta, Abdelwhab, El-Sayed M., Wessels, Ute, Mettenleiter, Thomas C., Stech, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549673/
https://www.ncbi.nlm.nih.gov/pubmed/26306544
http://dx.doi.org/10.1038/srep13493

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549673/
https://www.ncbi.nlm.nih.gov/pubmed/26306544
http://dx.doi.org/10.1038/srep13493

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