Increased Proinflammatory Cytokine Production and Decreased Cholesterol Efflux Due to Downregulation of ABCG1 in Macrophages Exposed to Indoxyl Sulfate

One of the possible causes of enhanced atherosclerosis in patients with chronic kidney disease (CKD) is the accumulation of uremic toxins. Since macrophage foam cell formation is a hallmark of atherosclerosis, we examined the direct effect of indoxyl sulfate (IS), a representative uremic toxin, on m...

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Detalles Bibliográficos
Autores principales: Matsuo, Koji, Yamamoto, Suguru, Wakamatsu, Takuya, Takahashi, Yoshimitsu, Kawamura, Kazuko, Kaneko, Yoshikatsu, Goto, Shin, Kazama, Junichiro J., Narita, Ichiei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549743/
https://www.ncbi.nlm.nih.gov/pubmed/26287243
http://dx.doi.org/10.3390/toxins7083155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549743/
https://www.ncbi.nlm.nih.gov/pubmed/26287243
http://dx.doi.org/10.3390/toxins7083155

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