Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editing

BACKGROUND: The ability to modify the genome of any cell at a precise location has drastically improved with the recent discovery and implementation of CRISPR/Cas9 editing technology. However, the capacity to introduce specific directed changes at given loci is hampered by the fact that the major ce...

Descripción completa

Detalles Bibliográficos
Autores principales: Robert, Francis, Barbeau, Mathilde, Éthier, Sylvain, Dostie, Josée, Pelletier, Jerry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550049/
https://www.ncbi.nlm.nih.gov/pubmed/26307031
http://dx.doi.org/10.1186/s13073-015-0215-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550049/
https://www.ncbi.nlm.nih.gov/pubmed/26307031
http://dx.doi.org/10.1186/s13073-015-0215-6

Ejemplares similares