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Pluripotency, Differentiation, and Reprogramming: A Gene Expression Dynamics Model with Epigenetic Feedback Regulation

Embryonic stem cells exhibit pluripotency: they can differentiate into all types of somatic cells. Pluripotent genes such as Oct4 and Nanog are activated in the pluripotent state, and their expression decreases during cell differentiation. Inversely, expression of differentiation genes such as Gata6...

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Detalles Bibliográficos
Autores principales: Miyamoto, Tadashi, Furusawa, Chikara, Kaneko, Kunihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550282/
https://www.ncbi.nlm.nih.gov/pubmed/26308610
http://dx.doi.org/10.1371/journal.pcbi.1004476