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Nrf2 and HSF-1 Pathway Activation via Hydroquinone-Based Proelectrophilic Small Molecules Is Regulated by Electrochemical Oxidation Potential
Activation of the Kelch-like ECH-associated protein 1/nuclear factor (erythroid-derived 2)-like 2 and heat-shock protein 90/heat-shock factor-1 signal-transduction pathways plays a central role in combatting cellular oxidative damage and related endoplasmic reticulum stress. Electrophilic compounds...
Autores principales: | Satoh, Takumi, Stalder, Romain, McKercher, Scott R., Williamson, Robert E., Roth, Gregory P., Lipton, Stuart A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550314/ https://www.ncbi.nlm.nih.gov/pubmed/26243592 http://dx.doi.org/10.1177/1759091415593294 |
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