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Epithelial Sodium Channel-Mediated Sodium Transport Is Not Dependent on the Membrane-Bound Serine Protease CAP2/Tmprss4

The membrane-bound serine protease CAP2/Tmprss4 has been previously identified in vitro as a positive regulator of the epithelial sodium channel (ENaC). To study its in vivo implication in ENaC-mediated sodium absorption, we generated a knockout mouse model for CAP2/Tmprss4. Mice deficient in CAP2/T...

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Detalles Bibliográficos
Autores principales: Keppner, Anna, Andreasen, Ditte, Mérillat, Anne-Marie, Bapst, Julie, Ansermet, Camille, Wang, Qing, Maillard, Marc, Malsure, Sumedha, Nobile, Antoine, Hummler, Edith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550455/
https://www.ncbi.nlm.nih.gov/pubmed/26309024
http://dx.doi.org/10.1371/journal.pone.0135224